GUEST EDITORIAL. Can sensitivity and specificity estimates from research studies be made more meaningful for clinical practice?

Reliability studies can be designed more efficiently by using variance components estimates from different sources.

OBJECTIVES Reliability studies are frequently organized within the context of a large (multicenter) study, with only a small sample of subjects measured by the observers of the large study. To estimate interobserver reliability, data from the large study are not frequently used. In this article, the advantages of combining data from the reliability study and the large study to improve the estim...

How can Health Behavior Theory be made more useful for intervention research?

BACKGROUND: The present paper expresses the author's views about the practical utility of Health Behavior Theory for health behavior intervention research. The views are skeptical and perhaps even a bit exaggerated. They are, however, also based on 20-plus years of in-the-trenches research focused on improving health behavior practice through research. DISCUSSION: The author's research has been...

Less Can Be More for Gene Dose and Drug Sensitivity.

CDK4 is preclinically validated as a therapeutic target in PAX3-FOXO1 fusion gene-positive rhabdomyosarcomas. Pharmacologic targeting showed sensitivity but, contrary to expectation, CDK4 genomic amplification and overexpression associated with 25% of cases that exhibited the lowest sensitivities. This emphasizes the importance of tumor-specific preclinical studies to define and understand drug...

Guest Editorial - Creative Design: Scaffolding Creative Reasoning and Meaningful Learning

ISSN 1436-4522. © International Forum of Educational Technology & Society (IFETS). The authors and the forum jointly retain the copyright of the articles. Permission to make digital or hard copies of part or all of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear the full citat...

Guest Editorial: Rethinking research training.